Non-alcoholic steatohepatitis: physiopathological, clinical and therapeutic implications

Non-alcoholic statohepatitis: physiopathological, clinical and therapeutic implications.

Non-Alcoholic Steatohepatitis: Pathogenesis and Clinical Management

1Division of Gastroenterology, Ospedale di Acireale, Azienda Sanitaria Provinciale di Catania, Catania, Italy 2Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel 3School of Public Health, University of Haifa, Haifa, Israel 4Department of Biomedical Sciences and Biotechnologies, University of Catania, Catania, Italy 5Center for Human Nutrition and Atkins Center...

Non-Alcoholic Steatohepatitis: Clinical and Translational Research.

UNLABELLED The present review includes translational and clinical research that characterize non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Clinical and experimental evidence led to the recognition of the key toxic role played by lipotoxicity in the pathogenesis of NAFLD. The current understanding of lipotoxicity suggests that organ injury is initiated by th...

Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies

Non-alcoholic steatohepatitis (NASH) is closely associated with progression to liver cirrhosis and hepatocellular carcinoma. We reported that melanocortin 4 receptor–defi cient mice (MC4R-KO mice), when fed a high-fat diet, provide a novel rodent model of NASH. Recently, we have identifi ed a unique histological feature termed “hepatic crown-like structures” (hCLS) in the livers of MC4R-KO mice...

Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention

Increased prevalence of non-alcoholic fatty liver disease (NAFLD) is one of the consequences of the current obesity epidemic. NAFLD is a major form of chronic liver disease that is highly prevalent in obese and overweight adults and children. Nonalcoholic steatohepatitis (NASH) is the severe form of NAFLD, and uncontrolled inflammation as displayed in NASH has been identified as one of the key ...